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What clinicians see is a much more uneven landscape of evidence, quality control, and regulatory status

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This could also support previous observations showing that AcM primarily exerts indirect effects on microbiota, with no or limited direct antibacterial activity on live cells [24]

The former represents a predictable pharmacokinetic principle that enables effective once-weekly dosing, while the latter would suggest inadequate elimination leading to toxicity

Geront 38 , 887895 (2003)